Parasitic RNA

Parasite RNA in plants, to contribute to the adjustment of long distance and local response to the environment and development of the plant. However, functional studies and cell ID of the RNA is hindered by the difficulty of specific trace of the RNA molecule from the cell of origin to the destination. It has been used for various methods to solve this problem, but are limited to some extent by the constraints associated with the detected RNA transport sampling or sieve SAP exactly all. To form a symplastic connections to the host, the parasitic some plants provide additional system for studying the transport of RNA. It is possible to send the mRNA of parasitic, viral RNA, and siRNA proteins in host plant, Haustorial of dodder seed Phelipanche links and are the same as those of the grafted them. Unlike other systems, the implant and these parasites, the high degree of nucleotide sequence, enables positive identification of most of the RNA parasite, the host system may be a difference between parasite and host Because there is not, I will form a connection with the host species that cover a wide phylogenetic spectrum. Host parasite RNA, and the ability to identify the reverse, to facilitate the approach of genomics to understand the RNA traffic. This assessment describes the potential importance of host RNA and parasites nature of the host parasite relationship. Host – Further Studies on parasite interactions, it is necessary to interpret the results of the transport studies RNA, but the parasitic plant can provide a new view of the RNA of the human compelling.

Protozoan parasites that affect humanity deeply represents malaria, toxoplasmosis, amoeba, Giardia, such as leishmaniasis and trypanosomiasis, a very diverse group of organisms. Many aspects that need to in spite of the significant impact of these parasites, open and how mechanisms of pathogenesis these organisms to survive in the host is left. Coupled with the increased availability of the genome that have been sequenced, RNA interference (RNAi) was discovered 13 years ago just in organisms not subject to classic genetic approach in particular, it is a very simple gene function is an analysis. In this case, we put a special emphasis on the use of the post-genomic tool to determine the current status of RNAi in the study of parasitic protozoa.

Affect the human race, in those caused by parasite malaria and disease, many, such as Leishmania major, for causing a high incidence of morbidity and mortality, and low-impact mainly, they or Africa South America trypanosomes, there is a great interest in public health – income populations in developing regions of Africa are often limited, Asia, North America, South American medical resources. In addition, affect the quality of life deeply, parasitic diseases have a major impact on the economic development of the whole country. I think usually, parasite infection and is more common in developing countries, but they also are popular in developed countries, trichomoniasis, toxoplasmosis and Giardia, have a significant impact in the United States. Chemotherapy is a powerful weapon against these parasites, the success of this approach is impaired by extensive resistance to some of the most effective drugs, including chloroquine in the treatment of malaria, have been developed so far are. Therefore, development of new treatments is urgent based on the evaluation and identification of drug targets potential.

Double-stranded RNA is (dsRNA can), a process called (RNAi) RNA interference found exclusive 1998, has a great impact on the side of the new winding eukaryotes that triggering the suppression of gene expression gene function in organisms that do not qualify for genetic classical approach particularly it had, which facilitates the analysis significantly post-genome era. Further, 20 and 30 nucleotides, antisense RNA, by opening a new world of small regulatory RNA, an enlarged still can be used as a therapeutic agent for small RNA, recognition that results in a small suppression of gene expression, large I want to improve the human disease that generated the expected.

In this section, we provide a view of the latest of RNAi pathway in parasitic protozoa, to discuss the usefulness of current and potential of RNAi as a tool. Not only chose to concentrate in organisms is not only important in terms of human disease, it is, we, and most, continue to be the subject of intense research in many laboratories around the world Importantly, of the RNAi to be examined for the presence of. (Wasting disease similar to sleeping sickness) pathogen of sleeping sickness, and these cruise that causes Chagas’ disease in South America, including T in the nagana cattle and humans in Africa (i) kinetoplastids Trypanosoma, sub-Saharan,, , agent of immunodeficiency New World Leishmania parasite old and causing various forms of world leishmaniasis, toxoplasmosis of (II) apicomplexans Plasmodium falciparum, of, the most deadly of the malaria parasite Toxoplasma human of the causative agent (IV) is the dysentery amoeba of diplomonad intestinal Giardia, causes a Giardia known as Bieber Fever serious threat, also (III) amoebozoa Entamoeba histolytica, and to individuals. Four groups of these organisms have a life style radically different if you are far away from each other evolutionarily.

Macrophages, trypanosome blood propagation as infection in immune cells of other living in phagocytosis lysosomes they Leishmania species that live in and T parasitophorous vacuole obligate intracellular parasite is Toxoplasma species and malaria. Giardia and dysentery to grow outside the cell in the gut environment, On the other hand, T. Cruise, will infect a variety of cell types in the vacuole of transition parasitophorous which is formed between the cell infiltration of the cytoplasm. Importantly, and that they are adapted to grow in laboratory techniques described above. All protozoan parasites have been developed for gene manipulation, their genome or is, is a process sequence.