Micro RNA is a small non-coding RNA molecules found in plants and animals to function in post-transcriptional regulation of transcription and gene expression. Usually, miRNA function pairing encoded by the nuclear DNA of eukaryotic organisms, and the sequence complementary to mRNA molecules, leading to gene silencing through degradation or translational repression of the target. It may encode a miRNA more than 1000 may be directed to approximately 60% of genes in the mammalian genome, and is abundant in human cell types most. miRNA has been conserved in eukaryotes well, it is believed to be an ancient component and important evolution of gene regulation. The main components of the micro-RNA pathway, are conserved between plants and animals, but look repertoire of miRNA in the two kingdoms, as has evolved independently a variety of functions. Typically, plant miRNA has a pairing perfect or nearly perfect and gene silencing by degradation of the target transcript and target RNA.
Plant miRNA may be coupled their goals in both the untranslated region and the coding region. In contrast to the miRNA Animal shows a partially complementary to the mRNA target only those in general. The region “seed 6-8 nucleotides is. Combinatorial regulation is considered an important factor for target specificity is a function of the adjustment of the miRNA is the length of the 5 ‘end of the miRNA Animal . it is possible to have a mRNA targets several different, also target the can,. miRNA being targeted by miRNA plurality was characterized in the early 1990s for the first time. Nevertheless, miRNA of the, miRNA is miRNA research., which is not recognized as a distinct class of regulatory biological with reservation function in the early 2000s, we show more than one role in the negative, blockade and degradation of (transcript, translational suppression rule if we may translational activation) and (transfer Joining possibility of regulation and positive), but affects gene regulation, miRNA expression in groups. variety that may be involved in the biological processes most The miRNA, it has been found in different types of cells, aberrant expression of. miRNA tissue is considered the treatment of miRNA-based and has been implicated in many disease states.
Before the publication of the discovery of those naming names of standard system, miRNA of verification is assigned experimentally. Prefix “peace” has continued and a number dash, the latter shows the sequence of naming often. The declared before, miR-123 is of, for example, of miR-456, it was discovered probably. The “meal” in the case of the, upper case, “meal” refers to the pre-miRNA refers to the mature form. MiRNA having a sequence substantially identical except for the nucleotides of one or two are annotated with minimal further. For example, Mir-123a is linked closely to the Mir-123b. Same as mature miRNA but preliminary miRNA leading to 100% and is arranged at different locations within the genome, is shown in dash extra suffix number. For example, two leads from the HSA-MIR-194, however, pre-miRNA is located in the different regions of the genome mature miRNA identical to the HSA-MIR-194-1 on (HSA-MIR-194). Species of origin is indicated by a prefix of three letters, for example, human HSA-MIR-123 is a (Homo sapiens) peace, sheep paddle-MIR-123 is the (sheep) Myrna. Prefix Other common, include “D” for the (study fly in genetic studies often fruit) for virus “V” (of miRNA encoded by the viral genome) peaceful and Drosophila have. When you derive from the opposite strand of the same pre-miRNA, they, two mature micro RNA is the suffix or-3P-5P labeled. (In the past, made this “S” difference ‘bottom’ and (sense) and (antisense)). After showing miRNA expression at low levels compared with the miRNA in the opposite side of the hairpin, the name when it is known asterisk relative levels of expression. For example, the hairpin of miR-123 * Sheapure and miRNA Mir -123, -123 peace will be found in the cell.
By genetic or their own micro RNA is produced by the intron. Video of this process can be found here. It is estimated for the antisense gene orientation adjacent or are intergenic, the majority of genes, wherein the miRNA and are transcribed as a single unit. However, in some cases, providing an average value of the protein-coding gene and adjustment of the miRNA that is transferred with the host gene micro RNA gene, it is coupled. 40% of miRNA gene may be located in exons of the transcripts encoding the long non-protein, or introns of a gene encoding a non-protein and protein. These are typically, but not exclusively, it is found in the sense orientation, and is adjusted with the genes of the host normally. The other genes, this does not mean that would be homologous to the structure and function mature miRNA family necessarily, but the promoter of miRNA the whole, polycistronic die having a line of discrete multiple be processed mature miRNA I show consists of 48% from 42 miRNA of all outgoing from. These promoters may have a similarity of pattern of the particular promoter gene transcription by other RNA polymerase II, such as a gene encoding such a protein is shown. The DNA template, there is no word at the end of the mature miRNA production: shows (IsomiRs) RNA editing, the site-specific modification of RNA sequences, 6% of the miRNA of human products, other than those encoded by the DNA were prepared. Range and diversity of action of miRNA will increase beyond the genome involved in it by this alone.